University of Regensburg Trenner Faculty of Chemistry Trenner Analytical Chemistry
Nanomaterials for Sensor Applications

List of Publications

h-index: 16


C. Würth, M. Kaiser, S. Wilhelm, B. Grauel, Th. Hirsch, U. Resch-Genger
  • Excitation power dependent population pathways and absolute quantum yields of upconversion nanoparticles in different solvents
  • Nanoscale, 2017, accepted. doi:10.1039/C7NR00092H
C. Genslein, P. Hausler, E.-M. Kirchner, R. Bierl, A.J. Baeumner, Th. Hirsch
  • Detection of small molecules with surface plasmon resonance by synergistic plasmonic effects of nanostructured surfaces and graphene
  • Proc. of SPIE, 2017, Vol 10077, 100800F-1-100800F-7. doi:10.1117/12.2252256
S. F. Himmelstoß, L. M. Wiesholler, M. Buchner, V. Muhr, S. Märkl, A. J. Baeumner, Th. Hirsch
  • 980 nm and 808 nm excitable upconversion nanoparticles for the detection of enzyme related reactions
  • Proc. of SPIE, 2017, Vol 10080, 100770L-1-100770L-6. doi:10.1117/12.2252381


M. del Barrio, R. Cases, V. Cebolla, Th. Hirsch, S. de Marcos, S. Wilhelm, J. Galbán
  • A reagentless enzymatic fluorescent biosensor for glucose based on upconverting glasses, as excitation source, and chemically modified glucose oxidase
  • Talanta, 2016, 160, 586-591. doi:10.1016/j.talanta.2016.07.062
C. Fenzl, C. Genslein, C. Domonkos, K. Edwards, Th. Hirsch, A.J. Baeumner
  • Investigating non-specific binding to chemically engineered sensor surfaces using liposomes as models
  • Analyst, 2016, 141(18), 5265-5273. doi:10.1039/C6AN00820H
A. Sedlmeier, A. Hlavácek, L. Birner, M. J. Mickert, V. Muhr, Th. Hirsch, P. L. A. M. Corstjens, H. J. Tanke, T. Soukka, H. H. Gorris
  • Highly Sensitive Laser Scanning of Photon-upconverting Nanoparticles on a Macroscopic Scale
  • Analytical Chemistry, 2016, 88(3), 1835-1841. doi:10.1021/acs.analchem.5b04147
C. Fenzl, Th. Hirsch, A. J. Baeumner
  • Nanomaterials as versatile tools for signal amplification in (bio)analytical applications
  • TrAC Trends in Analytical Chemistry, 2016, 79, 306-316. doi:10.1016/j.trac.2015.10.018
A. Zöpfl, M. Sisakthi, J. Eroms, F.-M. Matysik, C. Strunk, Th. Hirsch
  • Signal enhancement in amperometric peroxide detection by using graphene materials with low number of defects
  • Microchimica Acta, 2016, 183, 83-90. doi:10.1007/s00604-015-1600-y


E. Scheucher, S. Wilhelm, O.S. Wolfbeis, Th. Hirsch, T. Mayr
  • Composite particles with magnetic properties, near-infrared excitation, and far-red emission for luminescence-based oxygen sensing
  • Microsystems & Nanoengineering, 2015, 1, 15026 doi:10.1038/micronano.2015.26
C. Fenzl, Th. Hirsch, A.J. Baeumner
  • Liposomes with High Refractive Index Encapsulants as Tunable Signal Amplification Tools in Surface Plasmon Resonance Spectroscopy
  • Analytical Chemistry, 2015, 87(21), 11157-11163. doi:10.1021/acs.analchem.5b03405
C. Fenzl, C. Genslein, A. Zöpfl, A. J. Baeumner, Th. Hirsch
  • Photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors
  • Journal of Materials Chemistry B, 2015, 3, 2089-2095. doi: 10.1039/C4TB01970A
S. Wilhelm, M. Kaiser, Ch., J. Heiland, C. Carrillo-Carrion, V. Muhr, O. S. Wolfbeis, W. J. Parak, U. Resch-Genger, Th. Hirsch
  • Water Dispersible Upconverting Nanoparticles: Effects of Surface Modification on Luminescence and Colloidal Stability
  • Nanoscale, 2015, 7, 1403-1410. doi:10.1039/C4NR05954A
  • B. J. Sanghavi, O. S. Wolfbeis, Th. Hirsch, N. S. Swami
  • Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters
  • Microchimica Acta, 2015, 182, 1-41. doi:10.1007/s00604-014-1308-4


M.-M. Lemberger, Th. Hirsch. J. Wegener
  • Carbon Nanodots: Synthesis, Characterization, and Bioanalytical Applications
  • Bioanalytical Reviews, 2014, online first. doi:10.1007/11663_2014_11
  • V. Muhr, S. Wilhelm, Th. Hirsch, O. S. Wolfbeis
  • Upconversion Nanoparticles: From Hydrophobic to Hydrophilic Surfaces
  • Acc. Chem. Res., 2014, 47(12), 3481-3493. doi:10.1021/ar500253g
  • C. Fenzl, M. Kirchinger, Th. Hirsch, O. S. Wolfbeis
  • Photonic crystal based sensing and imaging of potassium ions
  • Chemosensors, 2014, 2(3), 207-218. doi:10.3390/chemosensors2030207
  • S. Wilhelm, M. del Barrio, J. Heiland, S. F. Himmelstoß, J. Galbán, O. S. Wolfbeis, Th. Hirsch
  • Spectrally Matched Upconverting Luminescent Nanoparticles for Monitoring Enzymatic Reactions
  • ACS Appl. Mater. Interfaces, 2014, 6(17), 15427–15433. doi:10.1021/am5038643
  • A. Zöpfl, M. M. Lemberger, M. König, G. Ruhl, F.-M. Matysik, Th. Hirsch
  • Reduced Graphene Oxide and Graphene Composite Materials for Improved Gas Sensing at Low Temperature
  • Faraday Discuss., 2014, 173 (1), 403-414. doi:10.1039/C4FD00086B
  • A. Zöpfl, W. Patterson, Th. Hirsch
  • Graphene for Biosensor Applications
  • in Handbook of Carbon Nano Materials, Volume 6: Graphene - Energy and Sensor Applications 2014, 83-145. doi:10.1142/9789814566704_0007
  • M. del Barrio, S. de Marcos, V. Cebolla, J. Heiland, S. Wilhelm, Th. Hirsch, J. Galban
  • Enzyme-induced Modulation of the Emission of Upconverting Nanoparticles: Towards a New Sensing Scheme for Glucose
  • Biosensors and Bioelectronics 2014, 59, 14-20. doi: 10.1016/j.bios.2014.02.076
  • C. Fenzl, Th. Hirsch, O.S Wolfbeis
  • Photonic Crystals for Chemical Sensing and Biosensing
  • Angew. Chem. Int. Ed. 2014, 53, 3318-3335. doi:10.1002/anie.201307828
  • Photonische Kristalle für die Chemo- und Biosensorik
  • Angew. Chem. 2014, 126, 3384-3402. doi:doi: 10.1002/ange.201307828
  • F. W. Scheller, A. Yarman, T. Bachmann, Th. Hirsch, S. Kubick, R. Renneberg, S. Schumacher, U. Wollenberger, C. Teller, F. F. Bier
  • Future of Biosensors: A Personal View
  • Biosensors Based on Aptamers and Enzymes Advances in Biochemical Engineering/Biotechnology, Volume 140, 2014, pp 1-28. doi:10.1007/10_2013_251


  • S. Wilhelm, Th. Hirsch, W. M. Patterson, E. Scheucher, T. Mayr, O. S. Wolfbeis
  • Protein-Reactive Multicolor Upconversion Nanoparticles
  • Theranostics 2013, 3, 239-248. doi:10.7150/thno.5113
  • P. Palatzky, A. Zöpfl, Th. Hirsch, F.-M. Matysik
  • Electrochemically Assisted Injection in Combination with Capillary Electrophoresis-Mass Spectrometry (EAI-CE-MS) – Mechanistic and Quantitative Studies of the Reduction of 4-Nitrotoluene at Various Carbon-Based Screen-Printed Electrodes
  • Electroanalysis 2013, 25, 117-122. doi:10.1002/elan.201200393


  • Ch. Fenzl, Th. Hirsch, O. S. Wolfbeis
  • Photonic Crystal Based Sensor for Organic Solvents and for Solvent-Water Mixtures
  • Sensors (Basel) 2012, 12, 16954-16963. doi:10.3390/s121216954
  • Ch. Fenzl, S. Wilhelm, Th. Hirsch, O. S. Wolfbeis
  • Optical Sensing of the Ionic Strength Using Photonic Crystals in a Hydrogel Matrix
  • ACS Applied Materials & Interfaces 2012, 5, 173-178. doi:10.1021/am302355g
  • S. Kochmann, Th. Hirsch, O. S. Wolfbeis
  • Graphenes in chemical sensors and biosensors.
  • TrAC 2012, 39, 87-113. doi:10.1016/j.trac.2012.06.004
  • Th. Lang, Th. Hirsch, Ch. Fenzl, F. Brandl, O. S. Wolfbeis
  • Surface Plasmon Resonance Sensor for Dissolved and Gaseous Carbon Dioxide.
  • Analytical Chemistry 2012, 84(21), 9085-9088. doi:10.1021/ac301673n
  • I.-S. Shin, Th. Hirsch, B. Ehrl, D.-H. Jang, O. S. Wolfbeis, and J.-I. Hong
  • Efficient fluorescence “turn-on” sensing of dissolved oxygen by electrochemical switching
  • Analytical Chemistry 2012, 84(21), 9163-9168. doi:10.1021/ac301830a


  • U. Lange, Th. Hirsch, V. M. Mirsky, Otto S. Wolfbeis
  • Hydrogen sensor based on a graphene – palladium nanocomposite.
  • Electrochimica Acta, 56 (10), 3707 – 3712. doi:10.1016/j.electacta.2010.10.078
  • C. Díez-Gil, R. Martínez, I. Ratera, Th. Hirsch, A. Espinosa, A. Tárraga, P. Molina, O. S. Wolfbeis, J. Veciana
  • Selective picomolar detection of mercury(II) using optical sensors.
  • Chem. Commun., 47, 1842 - 1844 doi:10.1039/C0CC04860G
  • S. Kochmann, Th. Hirsch, O. S. Wolfbeis
  • The pH Dependence of the Total Fluorescence of Graphite Oxide
  • J Fluoresc 22(3), 849-855, doi:10.1007/s10895-011-1019-8
  • S. M. Saleh, R. Ali, Th. Hirsch, O. S. Wolfbeis
  • Detection of biotin–avidin affinity binding by exploiting a self-referenced system composed of upconverting luminescent nanoparticles and gold nanoparticles.
  • J. Nanopart. Res. 2011, 13 (10), 4603 - 4611. doi:10.1007/s11051-011-0424-x
  • S. Wilhelm, Th. Hirsch, E. Scheucher, T. Mayr, O. S. Wolfbeis
  • Magnetic Nanosensor Particles with Luminescence Upconversion Capability.
  • Angew. Chemie Int. Edition 2011, 50 (37), A59-A62 (special pages provided by the DFG). doi:10.1002/anie.201105813
  • Angew. Chemie German Edition 2011, 123 (37), A59-A62 (special pages provided by the DFG). doi:10.1002/ange.201105813


  • A. Fassold, W. Falk, S. Anders, Th. Hirsch, V. M. Mirsky, R. H. Straub
  • Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis
  • Arthritis & Rheumatism 2009, 60, (10), 2892 – 2901. doi:10.1002/art.24860


  • Th. Hirsch, A. Shaporenko, V. M. Mirsky, M. Zharnikov
  • Monomolecular Films of Phthalocyanines: Formation, Characterization, and Expelling by Alkanethiols
  • Langmuir 2007, 23 (8), 4373 – 4377. doi:10.1021/la0634239


  • Th. Hirsch, M. Zharnikov, A. Shaporenko, J. Stahl, D. Weiss, O. S. Wolfbeis, V. M. Mirsky
  • Size-Controlled Electrochemical Synthesis of Metal Nanoparticles on Monomolecular Templates.
  • Angewandte Chemie Int. Edition 2005, 44 (41), 6775 – 6778. doi:10.1002/anie.200500912
  • Angewandte Chemie German Edition 1999, 117 (41), 6933 – 6936. doi:10.1002/ange.200500912


  • M. I. Prodromidis, Th. Hirsch, V. M. Mirsky, O. S. Wolfbeis
  • Enantioselective Artificial Receptors Formed by the Spreader-Bar Technique
  • Electroanalysis 2003, 15 (22), 1795 – 1798. doi:10.1002/elan.200302756
  • Th. Hirsch, H. Kettenberger, O. S. Wolfbeis, V. M. Mirsky
  • A simple strategy for preparation of sensor arrays: molecularly structured monolayers as recognition elements.
  • Chem. Commun. 2003, 432 - 433. doi:10.1039/B210554C


  • V. M. Mirsky, Th. Hirsch, T. L. Panasyuk, S. A. Piletsky, O. S. Wolfbeis
  • Two- and three-dimensional artificial chemoreceptors: molecular spreader-bar vs. molecular imprinting.
  • Med. Biol. Engineer. Comput. 1999, 37 (Suppl. 2), 344 - 345.
  • V. M. Mirsky, N. Wrobel, M. Riepl, Th. Hirsch, O. S. Wolfbeis
  • Intelligente Nanostrukturen fuer Biosensoren und Sensor-Arrays.
  • BioTec: Zeitschrift für Biotechnologie 1999, 10, 28-32.


  • V. Rehacek, I. Novotny, V. Tvarozek, M. Riepl, Th. Hirsch, M. Mass, R. Schweiss, V.M. Mirsky, O.S. Wolfbeis
  • Capacitive detection in thin film chemical sensors and biosensors
  • Advanced Semiconductor Devices and Microsystems 1998, 104 (45), 255 - 258. doi:10.1109/ASDAM.1998.730212

List of Patents

  • G. Ruhl, Th. Hirsch, A. Zöpfl
  • Graphene Gas Sensor for Measuring the Concentration of Carbon Dioxide in Gas Environments
  • US2015/0377824 A1; DE10204212282.1 (2015).
  • V. M. Mirsky, Th. Hirsch, O. S. Wolfbeis
  • Molecular imprinting with retaining the template molecule for applications as electrodes and other affinity surfaces.
  • WO9928047, PCT Int. Appl. (1999).
  • V. Mirsky, H. Kettenberger, C. Goedke, Th. Hirsch
  • Procedure and apparatus for degassing of liquid media.
  • DE10163083A1, Ger. Offen. (2003).

Book Chapter

  • Th. Hirsch
  • Artificial Receptors Based on Spreader-Bar Systems.
  • In Artificial Receptors for Chemical Sensors, V. Mirsky, A. Yatsimirsky (eds.), Wiley-VCH, Weinheim,2011, pp. 319 - 332. ISBN 978-527-32357-9

© 2008, Thomas Hirsch, Gisela Emmert.