Bioanalysis on the Micro- and Nanometer Scale

List of Publications

2013

•	H. H. Gorris, O. S. Wolfbeis Optical encoding and multiplexing of cells, biomolecules and microspheres using photon upconverting nanoparticles Angew. Chem. Int. Ed. 2013, accepted

2012

•	R. B. Liebherr, T. Soukka, O. S. Wolfbeis, H. H. Gorris Maleimide activation of photon upconverting nanoparticles for bioconjugation. Nanotechnologyt, 2012, 23(48) 485103 (7pp). doi:10.1088/0957-4484/23/48/485103
•	A. Sedlmeier, D. E. Achatz, L. H. Fischer, H. H. Gorris, O. S. Wolfbeis Photon upconverting nanoparticles for luminescent sensing of temperature. Nanoscale 2012, 4(22) 7090-7096. doi:10.1039/c2nr32314a
•	F. Martínez Ferreras, O. S. Wolfbeis, H. H. Gorris Dual lifetime referenced fluorometry for the determination of doxorubicin in urine. Anal. Chim. Acta 2012, 729, 62-66. doi:10.1016/j.aca.2012.03.050

2011

•	H. H. Gorris Nicht anketten, sondern einsperren: Wie man vielen einzelnen Enzymmolekülen in winzigen Kammern ihr Geheimnis entlockt. GIT Labor-Fachzeitschrift, August 2011
•	H. H. Gorris, S. Bade, N. Röckendorf, M. Fránek, A. Frey Pushing antibody-based labeling systems to higher sensitivity by linker-assisted affinity enhancement. Bioconjug. Chem. 2011, 22(8) 1619-1624. doi:10.1021/bc2001787
•	H. H. Gorris, S. M. Saleh, D. B. M. Groegel, S. Ernst, K. Reiner, H. Mustroph, O. S. Wolfbeis Long-Wavelength absorbing and fluorescent chameleon labels for proteins, peptides, and amines. Bioconjug. Chem. 2011, 22(7) 1433-1437. doi:10.1021/bc200192k
•	H. H. Gorris Sauerstoff sichtbar machen; Ratiometrische Messung der intrazellulären Sauerstoffverteilung. Laborpraxis, April 2011
•	X. D. Wang, H. H. Gorris, J. A. Stolwijk, R. J. Meier, D. B. M. Groegel, J. Wegener, O. S. Wolfbeis Self-referenced RGB colour imaging of intracellular oxygen. Chem. Sci. 2011, 2(5) 901-906. doi:10.1039/C0SC00610F News highlights about this article: a) Measuring cells' oxygen levels with PEBBLEs. Chemical World (RSC) 8.3.2011. b) Neues Verfahren macht Sauerstoff in Zellen sichtbar. Press release (University of Regensburg) 18.2.2011 c) Winzige Sensoren geben neue Einblicke. Mittelbayerische Zeitung 14.3.2011 d) Forscher machen Sauerstoff in Zellen sichtbar. Hamburger Abendblatt 22.2.2011
•	H. H. Gorris, R. Ali, S. M. Saleh,O. S. Wolfbeis Tuning the dual emission of photon-upconverting nanoparticles for ratiometric multiplexed encoding. Adv. Mater. 2011, 23(14) 1652-1655. doi:10.1002/adma.201004697

2010

•	S. Bade, H. H. Gorris, S. Kölling, V. Olivier, F. Reuter, P. Zabel, A. Frey Quantitation of major protein constituents of murine intestinal fluid. Anal. Biochem. 2010, 406 (2), 157-165. doi:10.1016/j.ab.2010.07.003
•	H. H. Gorris, D. R. Walt Analytical chemistry on the femtoliter scale. Angew. Chem. Int. Ed. 2010, 49(23), 3880-3895. doi:10.1002/anie.200906417
•	H. H. Gorris, D. R. Walt Analytische Chemie im Femtoliter. Angew. Chem. 2010, 122(23), 3970-3986. doi:10.1002/ange.200906417

2009

•	S. Bade, N. Röckendorf, M. Fránek, H. H. Gorris, B. Lindner, V. Olivier, K. J. Schaper, A. Frey Biolabeling with 2,4-dichlorophenoxyacetic acid derivatives: The 2,4-D tag Anal. Chem. 2009, 81(23), 9695-9702. doi:10.1021/ac901900n
•	H. H. Gorris, D. R. Walt Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies. J. Am. Chem. Soc. 2009, 131(17), 6277-6282. doi:10.1021/ja9008858
•	H. H. Gorris, S. Bade, N. Röckendorf, E. Albers, M. A. Schmidt, M. Fránek, A. Frey Rapid profiling of peptide stability in proteolytic environments. Anal. Chem. 2009, 81(4), 1580-1586. doi:10.1021/ac802324f
•	D. R. Walt, C. N. LaFratta, M. R. Webb, Z. Li, H. H. Gorris, R. Hayman Optical fiber microarrays for chemical and biological measurements. in Materials for optical sensors in biomedical applications 2009, edited by P. Kiesel, d. Nolte, X. Fan, G. Hong (Mater Res. soc. Symp. Proc. Volume 1133E, Warrendale, PA), 1133-AA02-01. doi: 10.1557/PROC-1133-AA02-01

2008

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D. M. Rissin, H. H. Gorris, D. R. Walt Distinct and long-lived activity states of single enzyme molecules. J. Am. Chem. Soc. 2008, 130(15), 5349-4353. doi:10.1021/ja711414f News highlights about this article: a) Distinctive individualism. Science 2008, 320 (5872) 22 (Editor’s choice). b) Faculty of 1000 Biology by Stuart S. Licht (7 Apr 2008)

2007

•	H. H. Gorris, D. M. Rissin, D. R. Walt Stochastic inhibitor release and binding from single-enzyme molecules. Proc. Natl. Acad. Sci. USA 2007, 104(45), 17680-17685. doi:10.1073/pnas.0705411104 News highlights about this article: a) Observing single enzymes at work. Chem. Eng. News 2007, 85 (44) 8. b) High-throughput, single-enzyme assay system. Anal. Chem. 2008, 80 (1) 5.
•	H. H. Gorris, T. M. Blicharz, D. R. Walt Optical-fiber bundles. FEBS J. 2007, 274(21), 5462-5470. (Review) doi:10.1111/j.1742-4658.2007.06078.x
•	N. Röckendorf, S. Bade, T. R. Hirst, H. H. Gorris, A. Frey Synthesis of a fluorescent ganglioside GM1 derivative and screening of a synthetic peptide library for GM1 binding sequence motifs. Bioconjug. Chem. 2007, 18(2) 573-578. doi:10.1021/bc0602376

List of Patents

•	D. M. Rissin, H. H. Gorris, D. R. Walt Methods and arrays for target analyte detection and determination of reaction components that affect a reaction. WO002007098148A3 (2007). One of the founding patents of Quanterix in Cambridge, MA, USA.
•	H. H. Gorris, S. Bade, N. Röckendorf, A. Frey Methods for determining the cleavability of substrates. WO002007051605A3 (2006).
•	S. Bade, N. Röckendorf, M. Franek, H. H. Gorris, A. Frey Kit comprising 2,4-dichlorophenoxyacetic acid derivatives and antibodies for highly sensitive detection assays. WO002007051603A3 (2006).
•	S. Bade, N. Röckendorf, H. H. Gorris, A. Frey Novel 2,4-dichlorophenoxyacetic acid derivatives and use thereof in diagnostic and analytical detection methods. WO002007051604A3 (2006).

Book Chapter

•	H. H. Gorris, S. Bade, A. Frey Peptidarrays auf Cellulosemembranen. In Gentechnische Methoden: Eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor, 4th edition, M. Jansohn (ed.), Spektrum Akademischer Verlag, München, pp. 519-544.

Public Presentations

•	Schülertag der Chemie 2012 Selbstgemachte Kristalle und mehr. Press release (University of Regensburg) 5.11.2012 Für die Schüler wurde Gummibärchen angekokelt. Mittelbayerische Zeitung 16.11.2012